Ozempic UK: Complete Guide
Ozempic (semaglutide) is a once-weekly injection for type 2 diabetes that has gained attention for its weight loss effects. This guide covers NHS access, private costs, how it works, and important safety information.
Active Ingredient
Semaglutide (0.25-1mg)
Licensed For
Type 2 Diabetes
Private Cost
£150-£250/month
How Taken
Weekly injection (pen)
What is Ozempic?
Ozempic is a prescription medication containing semaglutide, a GLP-1 receptor agonist developed by Novo Nordisk. It was approved by the MHRA for the treatment of type 2 diabetes in 2019 and is available on the NHS for eligible patients.
While Ozempic is licensed specifically for blood sugar control in type 2 diabetes, it has gained significant attention for its weight loss effects. However, it's important to note that Ozempic is not licensed for weight loss in the UK - that's what Wegovy (semaglutide 2.4mg) is for.
Ozempic works by mimicking the hormone GLP-1, which helps regulate blood sugar levels after eating, reduces appetite, and slows digestion. it's administered once weekly via a pre-filled injection pen.
What is Ozempic Used For?
- Type 2 diabetes - improving blood sugar control alongside diet and exercise
- Cardiovascular risk reduction - in T2D patients with established heart disease
- Weight loss - sometimes prescribed privately off-label, but Wegovy is the licensed option
- Off-label means using outside licensed indications - discuss risks with your prescriber
UK Availability: NHS vs Private
- Available for type 2 diabetes patients
- Usually after trying metformin or other medications
- Prescribed by GP or diabetes specialist
- Not available on NHS for weight loss alone
- £150-£250 per month (dose dependent)
- Available through registered online pharmacies
- Some prescribe off-label for weight loss
- Always verify GPhC registration
NHS Eligibility for Ozempic
To get Ozempic on the NHS, you generally need:
- A diagnosis of type 2 diabetes
- Inadequate blood sugar control on current medications
- Usually tried metformin first (unless contraindicated)
- BMI 35+ (or 30+ for certain ethnic backgrounds)
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How Ozempic Works
Ozempic contains semaglutide, which mimics a hormone called GLP-1 (glucagon-like peptide-1). This hormone is naturally released after eating and has several important effects:
Stimulates insulin release when blood sugar is high and reduces glucagon (which raises blood sugar).
Acts on brain receptors that control hunger, making you feel satisfied with less food.
Delays gastric emptying so food stays in your stomach longer, helping control blood sugar spikes.
Clinical trials show reduced risk of major cardiovascular events in people with type 2 diabetes.
Ozempic Dosing
Ozempic uses a gradual dose increase to minimise side effects. Your prescriber will determine the right dose based on your response.
| Dose | Purpose | Pen Type |
|---|---|---|
| 0.25mg | Starting dose (weeks 1-4) | 0.25/0.5mg pen |
| 0.5mg | Second dose level (weeks 5+) | 0.25/0.5mg pen |
| 1mg | Maintenance dose if needed | 1mg pen |
Each pen contains 4 weekly doses. Most people achieve good control at 0.5mg or 1mg weekly. Your doctor may adjust based on your HbA1c levels and tolerability.
Ozempic and Weight Loss
While Ozempic is not licensed for weight loss, many people taking it for diabetes experience significant weight reduction as a side effect:
4-6kg
Average weight loss at 1mg dose over 1 year
~5%
Average percentage of body weight lost
~15%
Weight loss with Wegovy (2.4mg dose)
Important Note About Weight Loss
If your primary goal is weight loss (not diabetes), Wegovy is the appropriate licensed medication. Using Ozempic off-label for weight loss means you're using it outside its approved indication, which has implications for insurance, liability, and medical support if issues arise.
Side Effects and Safety
Like all GLP-1 medications, Ozempic can cause side effects. Most are gastrointestinal and tend to improve as your body adjusts.
- Nausea (16-20% of people)
- Diarrhoea
- Vomiting
- Constipation
- Stomach pain
- Injection site reactions
- Pancreatitis
- Gallbladder problems
- Hypoglycaemia (with sulfonylureas/insulin)
- Diabetic retinopathy complications
- Allergic reactions
- Kidney problems (if dehydrated)
Who Should NOT Take Ozempic
- • Personal or family history of medullary thyroid cancer or MEN 2
- • Type 1 diabetes or diabetic ketoacidosis
- • History of pancreatitis
- • Pregnant, breastfeeding, or planning pregnancy
- • Allergic to semaglutide or any ingredients
Ozempic vs Other GLP-1 Medications
| Medication | Licensed For | Max Dose | Frequency |
|---|---|---|---|
| Ozempic | Type 2 Diabetes | 1mg | Weekly |
| Wegovy | Weight Loss | 2.4mg | Weekly |
| Mounjaro (Tirzepatide) | T2D & Weight Loss | 15mg | Weekly |
| Rybelsus | Type 2 Diabetes | 14mg | Daily (tablet) |
Frequently Asked Questions
Related Guides
References & Sources
- NICE NG28: Type 2 diabetes in adults - management. National Institute for Health and Care Excellence.
- Marso SP, et al. Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes. NEJM 2016.
- MHRA. Ozempic (semaglutide) Summary of Product Characteristics.
- Diabetes UK. GLP-1 agonists information and guidance.
Medical Disclaimer
This information is provided for educational purposes only and is not intended as medical advice. Ozempic is a prescription medication that requires assessment by a qualified healthcare professional. Always consult with your doctor or pharmacist before starting or changing any medication. If you're considering Ozempic for weight loss rather than diabetes, discuss appropriate licensed alternatives with your prescriber.
Last updated: December 2025
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