Cialis UK Guide 2025
The complete guide to Cialis (tadalafil) - the "weekend pill" that lasts up to 36 hours. Daily vs as-needed dosing, side effects, and how to get it safely in the UK.
Up to 36h
Duration
30-60 min
Time to work
Daily option
Available
How Cialis Works
Cialis contains tadalafil, a PDE5 inhibitor like Viagra. However, tadalafil has a much longer half-life, which is why its effects last up to 36 hours compared to 4-6 hours for sildenafil.
The mechanism is the same: by blocking the PDE5 enzyme, Cialis allows blood vessels in the penis to relax, increasing blood flow and making it easier to achieve an erection when sexually aroused.
Why "The Weekend Pill"?
Cialis's 36-hour window means you can take it Friday evening and still have its effects throughout the weekend - without needing to time doses around intimacy.
Daily vs As-Needed Cialis
Cialis is unique among ED medications in offering a daily dosing option. Here's how to choose:
When to take:
30-60 minutes before activity
Duration:
Up to 36 hours
Best for:
Men who have sex less than twice per week
Note: Maximum one dose per 24 hours
When to take:
Same time every day
Duration:
Continuous effect
Best for:
Men who have sex more than twice per week, or prefer spontaneity
Note: Takes 4-5 days to reach full effectiveness
Which Option is Right for You?
A healthcare provider can help you decide based on how often you're sexually active, your lifestyle preferences, and how you respond to the medication. Many men start with as-needed dosing and switch to daily if they prefer more spontaneity.
Side Effects
Common Side Effects
| Side Effect | Frequency |
|---|---|
| Headache | Up to 15% |
| Indigestion/heartburn | Up to 12% |
| Back pain | Up to 6% |
| Muscle aches | Up to 5% |
| Facial flushing | Up to 4% |
| Nasal congestion | Up to 4% |
Back pain and muscle aches are more common with Cialis than other ED medications, typically occurring 12-24 hours after taking it. They usually resolve within 48 hours.
- Priapism: An erection lasting more than 4 hours
- Sudden vision loss: Particularly in one eye
- Sudden hearing loss or ringing: May be accompanied by dizziness
- Chest pain during sex: Stop and seek help immediately
Who Should Not Take Cialis
Cialis is not suitable for everyone. Do not take Cialis if you:
- Take nitrates: For angina or heart conditions (includes GTN spray, isosorbide). Can cause dangerous blood pressure drops.
- Take alpha-blockers: For prostate problems or high blood pressure (dose adjustment may be needed)
- Have severe heart problems: Including recent heart attack, unstable angina, or uncontrolled heart failure
- Have had a stroke: Within the last 6 months
- Have low blood pressure: Or uncontrolled high blood pressure
- Have severe liver or kidney problems: Dose adjustment or avoidance may be needed
How to Get Cialis Safely in the UK
Unlike sildenafil (Viagra Connect), tadalafil is not available over the counter in the UK. You'll need a prescription from:
- Your GP: Can prescribe on the NHS for certain conditions, or provide a private prescription
- Online doctor services: Regulated services like those registered with the CQC can issue prescriptions after an online consultation
- Private clinics: Sexual health or men's health clinics
The original Eli Lilly product
£15-30 per tablet
Prices vary by pharmacy
Same active ingredient, MHRA approved
£1-5 per tablet
Significant savings available
Counterfeit Cialis is common. Always verify:
- Pharmacy is registered with the GPhC (check their register)
- Online services display the EU common logo for online pharmacies
- A proper consultation is required before dispensing
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Frequently Asked Questions
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Medical Disclaimer
This information is for educational purposes only and does not constitute medical advice. Erectile dysfunction can indicate underlying health conditions including cardiovascular disease. Always consult a healthcare provider before taking ED medication to ensure it's safe for you. Never take Cialis with nitrates.
Last updated: December 2025